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All hypertensive patients had no clinical signs, symptoms and laboratory findings suggesting secondary hypertension

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In human hypertension, an increase in the production of superoxide anions and hydrogen peroxide, a decrease in NO synthesis and a reduction in antioxidant bioavailability have been observed

BPC-157 demonstrates exceptional safety in animal toxicology studies, with comprehensive evaluations in mice, rats, rabbits, and dogs failing to establish a lethal dose (LD) across wide dose ranges extending from standard research doses (6 g/kg) to levels exceeding 1000-fold higher concentrations (20 mg/kg), with no evidence of acute toxicity, organ-specific damage, or systemic adverse effects even following repeated high-dose administration